interesting to note that previously, these researchers have
determined that cortical bone mass at the metacarpal bones is not a
potent predictor of hip fracture over long term follow up.
Can metacarpal cortical area predict the occurrence of hip
fracture in women and men over 3 decades of follow-up? Results from
the Framingham Osteoporosis Study.
Kiel DP, Hannan MT, Broe KE, Felson DT, Cupples LA.
J Bone Miner Res. 2001 Dec;16(12):2260-6.
Low Bone Mass Linked
to Heart Disease in Women
NEW YORK (Reuters Health) Mar 24
Low bone mass, as determined by the metacarpal cortical area,
predicts coronary heart disease in women, but not in men, according
to a new report. "If low bone mass and atherosclerosis share a
common pathogenesis, then strategies for prevention of osteoporosis
may, in turn, have implications for reduction of cardiovascular
disease risk," the investigators note. Although an inverse link
between bone mineral density and stroke has been reported in women,
no studies have looked at the ability of bone mass to predict
cardiovascular disease, lead author Dr. Elizabeth J. Samelson, from
Harvard Medical School in Boston, and colleagues state in the March
15th issue of the American Journal of Epidemiology. To investigate,
the researchers analyzed data from 1236 women and 823 men who
participated in The Framingham Study. The subjects were free from
cardiovascular disease at baseline (1967-1970) when hand x-rays were
taken. The participants were followed through the end of 1997 to
assess heart disease incidence. The rate of coronary heart disease
ranged from 11.76 to 15.65 cases/1000 person-years for women in the
highest to the lowest metacarpal cortical area quartile (p = 0.03).
In contrast, no association between heart disease risk and bone mass
was seen in men. The presence of a correlation only in women may
reflect sex-specific differences in how bone is mineralized, the
pathophysiology of heart disease, or both, the authors note. The
results suggest that boosting bone density may also prevent heart
disease, the Dr. Samelson and colleagues infer. "However, in
order to draw definitive conclusions regarding the implications of
these findings on the treatment or prevention of osteoporosis, we
need prospective studies that use current bone densitometry measures
and include both women and men to elucidate the etiologies of these
two important diseases."
EJ, Kiel DP, Broe KE, Zhang Y, Cupples LA, Hannan MT, Wilson PW,
Levy D, Williams SA, Vaccarino V. Metacarpal cortical area and risk
of coronary heart disease: the Framingham Study. Am J Epidemiol